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CD126 Antibody

Product Specifications

Gene Name

Interleukin 6 receptor

Gene Aliases

IL6Q, gp80, CD126, HIES5, IL-6R, IL6RA, IL6RQ, IL-1Ra, IL-6RA, IL6QTL, IL-6R-1

Gene ID

3570

Accession Number

NP_000556.1

Reactivity

Human

Target

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Clonality

Monoclonal

Clone

B-R6

Type

Monoclonal Antibody

Applications

FC, IP, IHC-F

Purification

Ion exchange chromatography

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1 ug/uL

Bioactivity

Blocks IL-6 induced proliferation of XG-1 cells, Inhibits IL-6 binding to its receptor, Recognises soluble and membrane bound IL-6 R

Format

Lyophilized

Buffer

Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free

Reconstitution

Stable at +2-8C for 12 months. For longer storage, freeze aliquots

Molecular Weight

52 kDa

Fragment

IgG1

Specificity

Recognises the Interleukin-6 Rα subunit, IL-6 Ra, IL-6 R, a 80 kDa protein

NCBI Gene Symbol

CD126

Host or Source

Mouse

Protein Name

Interleukin-6 receptor subunit alpha

Gene Name URL

CD126

CAS Number

9007-83-4

Nucleotide Accession Number

NM_000565.3

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