TIMP1 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
TIMP metallopeptidase inhibitor 1
Gene Aliases
CLGI; collagenase inhibitor; EPA; epididymis secretory sperm binding protein; EPO; erythroid potentiating activity; Erythroid-potentiating activity; fibroblast collagenase inhibitor; HCI; metalloproteinase inhibitor 1; TIMP; TIMP-1; tissue inhibitor of metalloproteinases 1.
Gene ID
7076
Accession Number
NP_003245.1
Reactivity
Human
Immunogen
Range: Thr25 - Ala207
Target
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
23 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against TIMP1. It has been selected for its ability to recognize TIMP1 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
TIMP1
Host or Source
Rabbit
Protein Name
Metalloproteinase inhibitor 1
Gene Name URL
TIMP1
Nucleotide Accession Number
NM_003254
Curated Selection
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