SIRPA Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Signal-regulatory protein alpha
Gene Aliases
AI835480; Bi; Bit; brain Ig-like molecule with tyrosine-based activation motifs; brain immunological-like with tyrosine-based motifs; CD172; CD172 antigen-like family member A; CD172a; Idd13.2; inhibitory receptor SHPS-1; mSIRP-alpha1; myD-1 antigen; P8; P84; protein tyrosine phosphatase, non-receptor type substrate 1; Pt; Ptpns1; SHP; SHP substrate 1; SHP-1; SHPS-1; signal-regulatory protein alpha-1; SIRP; sirp-alpha-1; tyrosine-protein phosphatase non-receptor type substrate 1.
Gene ID
19261
Accession Number
NP_001171118.1
Reactivity
Human|Mouse
Immunogen
Range: Thr56 - Arg296
Target
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
32 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against SIRPa. It has been selected for its ability to recognize SIRPa in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Sirpa
Host or Source
Rabbit
Protein Name
Tyrosine-protein phosphatase non-receptor type substrate 1
Gene Name URL
Sirpa
Nucleotide Accession Number
NM_001177647
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