PTPRS Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Protein tyrosine phosphatase, receptor type, S

Gene Aliases

AL022616; PTP; PTP-; PTPNU-3; PTP-NU3; PTPsigma; Ptpt9; receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma; RPT; R-PTP-S; RPTPsigma; R-PTP-sigma; tissue-specific protein tyrosine phosphatase.

Gene ID

19280

Accession Number

NP_001239382.1

Reactivity

Mouse|Rat

Immunogen

Range: Arg889 - His1102

Target

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:19833921, PubMed:21454754, PubMed:22406547) . Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (PubMed:21454754) . Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:15797710, PubMed:19833921, PubMed:19780196, PubMed:21454754, PubMed:22519304, PubMed:22406547) . Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754) . Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (PubMed:10080191) . Functions as tyrosine phosphatase (PubMed:7529177) . Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity) . Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (PubMed:15797710) . Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120) .

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

Immunohistochemistry|Western blot

Purification

Affinity Purified; Protein A Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Format

Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Reconstitution

2°C to 8°C|-20°C

Molecular Weight

68 kDa

Fragment

IgG

Specificity

The antibody is a rabbit polyclonal antibody raised against PTPRS. It has been selected for its ability to recognize PTPRS in immunohistochemical staining and western blotting.