PTPRS Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Protein tyrosine phosphatase receptor type S
Gene Aliases
Protein tyrosine phosphatase PTPsigma; PTPSIGMA; receptor-type tyrosine-protein phosphatase S; receptor-type tyrosine-protein phosphatase sigma; R-PTP-S; R-PTP-sigma.
Gene ID
5802
Accession Number
NP_002841.3
Reactivity
Human|Mouse|Porcine|Rat
Immunogen
Range: Arg77 - Gly361
Target
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754) . Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829) . Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity) . Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity) . Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
168 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against PTPRS. It has been selected for its ability to recognize PTPRS in immunohistochemical staining and western blotting.
NCBI Gene Symbol
PTPRS
Host or Source
Rabbit
Protein Name
Receptor-type tyrosine-protein phosphatase S
Gene Name URL
PTPRS
Nucleotide Accession Number
NM_002850
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