PTPRB Antibody
Product Specifications
Gene Name
Protein tyrosine phosphatase, receptor type, B
Gene Aliases
3230402H02Rik; C130094E24; protein-tyrosine phosphatase beta; Ptpz; receptor-type tyrosine-protein phosphatase beta; Rptpb; R-PTP-beta; vascular endothelial protein tyrosine phosphatase; VE-; Veptp; VE-PTP.
Gene ID
19263
Accession Number
NP_084204.2
Reactivity
Mouse
Immunogen
Recombinant PTPRB (Gly1214~Val1463) expressed E.coli
Target
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunohistochemistry|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
224 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against PTPRB. It has been selected for its ability to recognize PTPRB in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Ptprb
Host or Source
Rabbit
Protein Name
Receptor-type tyrosine-protein phosphatase beta
Gene Name URL
Ptprb
CAS Number
9007-83-4
Nucleotide Accession Number
NM_029928
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