PSMD10 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Proteasome 26S subunit, non-ATPase 10

Gene Aliases

26S proteasome non-ATPase regulatory subunit 10;26S proteasome regulatory subunit p28; ankyrin repeat protein; dJ889N15.2; gankyrin; hepatocellular carcinoma-associated protein p28-II; p28; p28 (GANK) ; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.

Gene ID

5716

Accession Number

NP_002805.1

Reactivity

Human

Immunogen

Range: Met1 - Gly226

Target

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC) . In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified; Protein A Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Format

Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Reconstitution

2°C to 8°C|-20°C

Molecular Weight

16 kDa

Fragment

IgG

Specificity

The antibody is a rabbit polyclonal antibody raised against PSMD10. It has been selected for its ability to recognize PSMD10 in immunohistochemical staining and western blotting.