PSMD10 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Proteasome 26S subunit, non-ATPase 10
Gene Aliases
26S proteasome non-ATPase regulatory subunit 10;26S proteasome regulatory subunit p28; ankyrin repeat protein; dJ889N15.2; gankyrin; hepatocellular carcinoma-associated protein p28-II; p28; p28 (GANK) ; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.
Gene ID
5716
Accession Number
NP_002805.1
Reactivity
Human
Immunogen
Range: Met1 - Gly226
Target
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC) . In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunohistochemistry|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
16 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against PSMD10. It has been selected for its ability to recognize PSMD10 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
PSMD10
Host or Source
Rabbit
Protein Name
26S proteasome non-ATPase regulatory subunit 10
Gene Name URL
PSMD10
Nucleotide Accession Number
NM_002814
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