PRTN3 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Proteinase 3
Gene Aliases
ACPA; AGP7; azurophil granule protein 7; CANCA; C-ANCA; C-ANCA antigen; leukocyte proteinase 3; MBN; MBT; myeloblastin; neutrophil proteinase 4; NP4; NP-4; P29; PR3; PR-3; serine proteinase, neutrophil; wegener autoantigen; Wegener granulomatosis autoantigen.
Gene ID
5657
Accession Number
NP_002768.3
Reactivity
Human|Mouse|Rat
Immunogen
Range: His71 - Leu247
Target
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246) . By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369) . May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
28 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against PR3. It has been selected for its ability to recognize PR3 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
PRTN3
Host or Source
Rabbit
Protein Name
Myeloblastin
Gene Name URL
PRTN3
Nucleotide Accession Number
NM_002777
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