NME1 Antibody
Product Specifications
Gene Name
NME/NM23 nucleoside diphosphate kinase 1
Gene Aliases
AWD; epididymis secretory sperm binding protein; GAAD; granzyme A-activated DNase; metastasis inhibition factor nm23; NB; NBS; NDKA; NDP kinase A; NDPKA; NDPK-A; NM23; NM23-H1; non-metastatic cells 1, protein (NM23A) expressed in; nucleoside diphosphate kinase A; tumor metastatic process-associated protein.
Gene ID
4830
Accession Number
NP_000260.1
Reactivity
Human
Immunogen
Range: Met1 - Glu152
Target
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
17 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against NME1. It has been selected for its ability to recognize NME1 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
NME1
Host or Source
Rabbit
Protein Name
Nucleoside diphosphate kinase A
Gene Name URL
NME1
CAS Number
9007-83-4
Nucleotide Accession Number
NM_000269
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