MASP1 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Mannan-binding lectin serine peptidase 1

Gene Aliases

AW048060; CCPII; complement factor MASP-3; complement-activating component of Ra-reactive factor; Cr; Crarf; mannan-binding lectin serine protease 1; mannose-binding lectin-associated serine protease 1; mannose-binding protein-associated serine protease; MASP-1; Masp1/3; ra-reactive factor serine protease p100; raRF; serine protease 5.

Gene ID

17174

Accession Number

NP_032581.2

Reactivity

Human|Mouse|Rat

Immunogen

Range: His25 - Arg453

Target

Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development.

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

Immunohistochemistry|Western blot

Purification

Affinity Purified; Protein A Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Format

Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Reconstitution

2°C to 8°C|-20°C

Molecular Weight

80 kDa

Fragment

IgG

Specificity

The antibody is a rabbit polyclonal antibody raised against MASP1. It has been selected for its ability to recognize MASP1 in immunohistochemical staining and western blotting.