MASP1 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
MBL associated serine protease 1
Gene Aliases
3MC1; C4/C2 activating component of Ra-reactive factor; complement factor MASP-3; complement-activating component of Ra-reactive factor; CRARF; CRARF1; mannan binding lectin serine peptidase 1; mannan-binding lectin serine protease 1; mannose-associated serine protease 1; mannose-binding lectin-associated serine protease 1; mannose-binding protein-associated serine protease; MAP1; MAP-1; MAp44; MASP; MASP3; MASP-3; PRSS5; Ra-reactive factor serine protease p100; RaRF; serine protease 5.
Gene ID
5648
Accession Number
NP_001027019.1
Reactivity
Human|Mouse
Immunogen
Range: His20 - Ala447
Target
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunohistochemistry|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
44 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against MASP1. It has been selected for its ability to recognize MASP1 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
MASP1
Host or Source
Rabbit
Protein Name
Mannan-binding lectin serine protease 1
Gene Name URL
MASP1
Nucleotide Accession Number
NM_001031849
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