MAPK7 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Mitogen-activated protein kinase 7
Gene Aliases
B2b2346C; b2b2346Clo; big MAP kinase 1; BMK1; BMK-1; ERK; ERK5; Erk5-; ERK-5; Erk5-T; extracellular signal-regulated kinase 5; MAPK 7; mitogen-activated protein kinase 7; PRKM7.
Gene ID
23939
Accession Number
NP_001277962.1
Reactivity
Mouse
Immunogen
Range: Pro185 - Met419
Target
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity) . Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
56 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against MAPK7. It has been selected for its ability to recognize MAPK7 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Mapk7
Host or Source
Rabbit
Protein Name
Mitogen-activated protein kinase 7
Gene Name URL
Mapk7
Nucleotide Accession Number
NM_001291033
Curated Selection
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