Nurr1 agonist 11
Nurr1 agonist 11 (compound 53) is a selective and potent Nurr1 agonist with an IC50 of 26 µM. Nurr1 agonist 11 has the ability to cross a cellular model of the blood-brain-barrier (BBB) [1].
Product Specifications
CAS Number
1090335-04-8
UNSPSC
12352005
Target
Nuclear Hormone Receptor 4A/NR4A
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nurr1-agonist-11.html
Smiles
CN(C(CCC1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)O1)=O)C
Molecular Formula
C20H20N2O2
Molecular Weight
320.39
References & Citations
[1]Willems S, et al. Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism. J Med Chem. 2024 Aug 8;67 (15) :13324-13348.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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