LYAR Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Ly1 antibody reactive clone
Gene Aliases
Cell growth-regulating nucleolar protein; ly1 antibody-reactive protein; MLZ-264; protein expressed in male leptotene and zygotene spermatocytes 264.
Gene ID
17089
Accession Number
NP_079557.2
Reactivity
Human|Mouse|Rat
Immunogen
Range: Gly270 - Lys388
Target
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity) . Also acts at the level of transcription regulation. Along with PRMT5, binds embryonic globin promoter (By similarity) . Represses the expression of embryonic globin Hbb-y gene (PubMed:25092918) . In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41 (By similarity) . Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity) . Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (PubMed:25735755) . Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (PubMed:19489080) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
44 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against LYAR. It has been selected for its ability to recognize LYAR in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Lyar
Host or Source
Rabbit
Protein Name
Cell growth-regulating nucleolar protein
Gene Name URL
Lyar
Nucleotide Accession Number
NM_025281
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1190340-01 0.5 mg (E-Coli)
Recombinant Saccharomyces cerevisiae Suppressor of lethality of KEX2 GAS1 double null mutant protein 1 (SKG1), partial
Ask
View Details 
MBS1190340-02 0.05 mg (Baculovirus)
Recombinant Saccharomyces cerevisiae Suppressor of lethality of KEX2 GAS1 double null mutant protein 1 (SKG1), partial
Ask
View Details MBS1190340-03 0.5 mg (Yeast)
Recombinant Saccharomyces cerevisiae Suppressor of lethality of KEX2 GAS1 double null mutant protein 1 (SKG1), partial
Ask
View Details