CD300LF Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
CD300 molecule like family member F
Gene Aliases
CD300 antigen like family member F; CD300 antigen-like family member F; CLIM1; CLM1; CLM-1; CMRF35-like molecule 1; CMRF-35-like molecule 1; DC-derived Ig-like receptor 2; DIg; Digr2; F730004D16Rik; IgSF; IgSF13; IRE; IREM1; leukocyte mono-Ig-like receptor 3; LM; LMIR3; MAIR-5; MAIR-V; myeloid-associated immunoglobulin-like receptor 5; Pi; Pigr3.
Gene ID
246746
Accession Number
NP_001162624.1
Reactivity
Human|Mouse
Immunogen
Recombinant CD300LF (Ser45 - Ile310) expressed in E.coli.
Target
Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:17438331) . Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells (PubMed:21865548) . Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (PubMed:26768664) . Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide which acts as a ligand (PubMed:23123064) . May act as a coreceptor for interleukin 4 (IL-4) . Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (PubMed:26124135) . Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity) . Inhibits osteoclast formation (PubMed:14662855) . Induces macrophage cell death upon engagement (PubMed:18097021) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against IREM1. It has been selected for its ability to recognize IREM1 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Cd300lf
Host or Source
Rabbit
Protein Name
CMRF35-like molecule 1
Gene Name URL
Cd300lf
Nucleotide Accession Number
NM_001169153
Curated Selection
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