FPS-ZM1
FPS-ZM1 is a high-affinity RAGE inhibitor with a Ki of 25 nM.
Product Specifications
CAS Number
945714-67-0
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/FPS-ZM1.html
Purity
99.87
Solubility
DMSO : 58.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1
Molecular Formula
C20H22ClNO
Molecular Weight
327.85
Precautions
H315, H319, H335
References & Citations
[1]Deane R, et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr;122 (4) :1377-92.|[2]Hong Y, et al. Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem Res. 2016 May;41 (5) :1192-9.|[3]Lian YJ, et al. Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1. Brain Behav Immun. 2017 Jan;59:322-332.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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