FPS-ZM1

FPS-ZM1 is a high-affinity RAGE inhibitor with a Ki of 25 nM.

Product Specifications

CAS Number

[945714-67-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/FPS-ZM1.html

Purity

99.87

Solubility

DMSO : 58.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1

Molecular Formula

C20H22ClNO

Molecular Weight

327.85

Precautions

H315, H319, H335

References & Citations

[1]Deane R, et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr;122 (4) :1377-92.|[2]Hong Y, et al. Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem Res. 2016 May;41 (5) :1192-9.|[3]Lian YJ, et al. Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1. Brain Behav Immun. 2017 Jan;59:322-332.