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HSD17B12 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Hydroxysteroid (17-beta) dehydrogenase 12

Gene Aliases

17-beta-HSD 12;17-beta-hydroxysteroid dehydrogenase 12;2610510O05Rik;3-ketoacyl-CoA reductase; AI172963; estradiol 17-beta-dehydrogenase 12; KAR; keratoadhesin; keratonectin; KIK; Kik1; KIK-I; steroid dehydrogenase; very-long-chain 3-oxoacyl-CoA reductase.

Gene ID

56348

Accession Number

NP_062631.1

Reactivity

Mouse

Immunogen

Recombinant HSD17b12 (Met1~Asn312) expressed in E.coli

Target

Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.

Clonality

Polyclonal

Type

Polyclonal Antibody

Source

Polyclonal antibody preparation

Applications

Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

Purification

Affinity Purified; Protein A Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Format

Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Reconstitution

2°C to 8°C|-20°C

Molecular Weight

20 kDa

Fragment

IgG

Specificity

The antibody is a rabbit polyclonal antibody raised against HSD17b12. It has been selected for its ability to recognize HSD17b12 in immunohistochemical staining and western blotting.

NCBI Gene Symbol

Hsd17b12

Host or Source

Rabbit

Protein Name

Very-long-chain 3-oxoacyl-CoA reductase

Gene Name URL

Hsd17b12

Nucleotide Accession Number

NM_019657

Frequently Asked Questions

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