FCGR3A Antibody

4833442P21Rik; CD16-2; Fc fragment of IgG, low affinity IIIa, receptor for (CD16) ; Fc fragment of IgG, low affinity III, receptor for (CD16) ; Fc gammaRIV; Fc receptor-like 3; Fcgam; FcgammaRIV; Fcgr; Fcgr3a; FcgRIV; Fcrl3; low affinity immunoglobulin gamma Fc region receptor III-A; low affinity immunoglobulin gamma Fc region receptor IV.

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578) . Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059) . Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417) . Can bind to IgG2a and IgG2b monomers (PubMed:18949059) . Does not display binding to IgG1 or IgG3 (PubMed:16039578) . Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064) . Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719) . Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059) . Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411) . Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059) . Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059) .

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

The antibody is a rabbit polyclonal antibody raised against FcgR3A. It has been selected for its ability to recognize FcgR3A in immunohistochemical staining and western blotting.