What is the catalog number for DKK1 Antibody?

The catalog number for DKK1 Antibody is OACD03057-100UL.

What sizes are available for DKK1 Antibody?

DKK1 Antibody is available in the following size(s): 100 µL.

Is DKK1 Antibody in stock?

DKK1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

DKK1 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Dickkopf WNT signaling pathway inhibitor 1

Gene Aliases

Dickkopf 1 homolog; dickkopf-1 like; dickkopf-like protein 1; dickkopf-related protein 1; DKK-1; SK.

Gene ID

22943

Accession Number

NP_036374.1

Reactivity

Human|Mouse|Porcine|Rat

Immunogen

Range: Leu33 - His266

Target

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856) . DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291) . Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity) .

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

Purification

Affinity Purified; Protein A Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

Varies by lot. See vial for concentration.

Format

Liquid// PBS (pH 7.4) containing 0.02% sodium azide and 50% glycerol

Reconstitution

Store at 4° C for frequent use. Aliquot and store at -20° C for 24 months. Avoid repeated freeze/thaw cycles.

Molecular Weight

29 kDa

Fragment

IgG

Specificity

The antibody is a rabbit polyclonal antibody raised against DKK1. It has been selected for its ability to recognize DKK1 in immunohistochemical staining and western blotting.