DEFB126 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Defensin beta 126
Gene Aliases
BA530N10.1; beta-defensin 126; Beta-defensin 26; C20orf8; DEFB26; DEFB-26; Defensin, beta 126; Epididymal secretory protein 13.2; epididymal secretory protein ESP13.2; epididymis secretory sperm binding protein; hBD-26; HBD26.
Gene ID
81623
Accession Number
NP_112193.1
Reactivity
Human
Immunogen
Range: Asn21 - Gly111
Target
Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (By similarity) . In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (PubMed:19373462, PubMed:23229569) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunohistochemistry|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
12 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against DEFb126. It has been selected for its ability to recognize DEFb126 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
DEFB126
Host or Source
Rabbit
Protein Name
Beta-defensin 126
Gene Name URL
DEFB126
Nucleotide Accession Number
NM_030931
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