CASP1 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Caspase 1, apoptosis-related cysteine peptidase
Gene Aliases
CASP-1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) ; caspase-1; ICE; IL-1 beta-converting enzyme; IL-1BC; interleukin-1 beta convertase; interleukin-1 beta converting enzyme; Interleukin-1 beta-converting enzyme; p45.
Gene ID
397319
Accession Number
NP_999327.1
Reactivity
Human|Porcine
Immunogen
Recombinant CASP1 (Asn120~Asp297) expressed in E.coli
Target
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs) . Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive.
Clonality
Polyclonal
Type
Polyclonal Antibody
Source
Polyclonal antibody preparation
Applications
Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against CASP1. It has been selected for its ability to recognize CASP1 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
CASP1
Host or Source
Rabbit
Protein Name
Caspase-1
Gene Name URL
CASP1
Nucleotide Accession Number
NM_214162
Curated Selection
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