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C4A Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Complement C4A (Rodgers blood group) |complement C4B (Chido blood group)

Gene Aliases

Acidic C4; acidic complement C4; basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; C4; C4A anaphylatoxin; C4A2; C4A3; C4A4; C4A6; C4AD; C4B_2; C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4F; C4S; CH; Chido form of C4; CO4; complement C4-A; complement C4-B; complement C4B1a; complement component 4A (Rodgers blood group) ; complement component 4B (Chido blood group) ; CPAMD2; CPAMD3; MHC class III region complement; RG; Rodgers form of C4.

Gene ID

720|721

Accession Number

NP_001002029.3

Reactivity

Human

Immunogen

Recombinant Complement Component 4 (Asn975~Arg1336) expressed in E.coli.

Target

Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

Purification

Affinity Purified; Protein A Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.7 mg/ml

Format

Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Reconstitution

2°C to 8°C|-20°C

Molecular Weight

188 kDa

Fragment

IgG

Specificity

The antibody is a rabbit polyclonal antibody raised against C4. It has been selected for its ability to recognize C4 in immunohistochemical staining and western blotting.

NCBI Gene Symbol

C4A|C4B

Host or Source

Rabbit

Protein Name

Complement C4-A

Gene Name URL

C4A|C4B

Nucleotide Accession Number

NM_001002029

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