Icariin

Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.

Product Specifications

CAS Number

[489-32-7]

Product Name Alternative

Ieariline

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Autophagy; Phosphodiesterase (PDE) ; PPAR

Type

Natural Products

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Icariin.html

Purity

99.06

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=C(C/C=C(C)/C)C(OC(C3=CC=C(OC)C=C3)=C(O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)C5=O)=C5C(O)=C2)[C@@H]1O

Molecular Formula

C33H40O15

Molecular Weight

676.66

Precautions

H315, H319, H335

References & Citations

[1]Xin ZC, et al. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl. 2003 Mar;5 (1) :15-8.|[2]Lu YF, et al. Icariin is a PPARα activator inducing lipid metabolic gene expression in mice. Molecules. 2014 Nov 6;19 (11) :18179-91.|[3]Hu Y, et al. Effects and mechanisms of icariin on atherosclerosis. Int J Clin Exp Med. 2015 Mar 15;8 (3) :3585-9.|[4]Chen M, et al. Effects of icariin on reproductive functions in male rats. Molecules. 2014 Jul 3;19 (7) :9502-14.|[5]Liu D, et al. Icariin protects rabbit BMSCs against OGD-induced apoptosis by inhibiting ERs-mediated autophagy via MAPK signaling pathway. Life Sci. 2020 Apr 26:117730.