What is the catalog number for PTTG1 Antibody?

The catalog number for PTTG1 Antibody is OACD00991-1ML.

What sizes are available for PTTG1 Antibody?

PTTG1 Antibody is available in the following size(s): 1 mL.

Is PTTG1 Antibody in stock?

PTTG1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

PTTG1 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Pituitary tumor-transforming gene 1

Gene Aliases

AW555095; C87862; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1 protein; PTT; Pttg; Pttg3; sec; securin.

Gene ID

30939

Accession Number

NP_001124526.1

Reactivity

Human|Mouse|Rat

Immunogen

Range: Ala2 - Ile199

Target

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity) .

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

Purification

Affinity Purified; Protein A Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Format

Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Reconstitution

2°C to 8°C|-20°C

Molecular Weight

20 kDa

Fragment

IgG

Specificity

The antibody is a rabbit polyclonal antibody raised against PTTG1. It has been selected for its ability to recognize PTTG1 in immunohistochemical staining and western blotting.