PTPN22 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Protein tyrosine phosphatase non-receptor type 22

Gene Aliases

Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LYP; LYP1; LYP2; PEP; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid) ; protein tyrosine phosphatase, non-receptor type 8; PTPN22.5; PTPN22.6; PTPN8; tyrosine-protein phosphatase non-receptor type 22.

Gene ID

26191

Accession Number

NP_001180360.1

Reactivity

Human|Porcine

Immunogen

Range: Met1 - Arg233

Target

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643) . Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704) . Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343) . Dephosphorylates the immune system activator SKAP2 (PubMed:21719704) . Positively regulates toll-like receptor (TLR) -induced type 1 interferon production (PubMed:23871208) . Promotes host antiviral responses mediated by type 1 interferon (By similarity) . Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106) .

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified; Protein A Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Format

Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Reconstitution

2°C to 8°C|-20°C

Molecular Weight

21 kDa

Fragment

IgG

Specificity

The antibody is a rabbit polyclonal antibody raised against PTPN22. It has been selected for its ability to recognize PTPN22 in immunohistochemical staining and western blotting.