DLG5 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Discs large MAGUK scaffold protein 5
Gene Aliases
Discs large protein LP-DLG; discs large protein P-dlg; discs, large homolog 5; disks large homolog 5; large type of P-DLG; LP-DLG; PDLG; P-DLG5; placenta and prostate DLG.
Gene ID
9231
Accession Number
NP_004738.3
Reactivity
Human
Immunogen
Range: Asp1722 - Asn1905
Target
Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360) . Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714) . Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360) . Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunohistochemistry|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
74 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against DLG5. It has been selected for its ability to recognize DLG5 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
DLG5
Host or Source
Rabbit
Protein Name
Disks large homolog 5
Gene Name URL
DLG5
Nucleotide Accession Number
NM_004747
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
