TNKS2 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Tankyrase 2

Gene Aliases

ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; PARP-5b; PARP5B; PARP-5c; PARP5C; pART6; poly [ADP-ribose] polymerase 5B; poly [ADP-ribose] polymerase tankyrase-2; protein poly-ADP-ribosyltransferase tankyrase-2; TANK2; tankyrase II; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; tankyrase-like protein; tankyrase-related protein; TNKL; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2.

Gene ID

80351

Accession Number

NP_079511.1

Reactivity

Human

Immunogen

Range: Ser959 - Gly1166

Target

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

Immunohistochemistry|Western blot

Purification

Affinity Purified; Protein A Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Format

Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Reconstitution

2°C to 8°C|-20°C

Molecular Weight

127 kDa

Fragment

IgG

Specificity

The antibody is a rabbit polyclonal antibody raised against TNKS2. It has been selected for its ability to recognize TNKS2 in immunohistochemical staining and western blotting.