TNKS2 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Tankyrase 2
Gene Aliases
ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; PARP-5b; PARP5B; PARP-5c; PARP5C; pART6; poly [ADP-ribose] polymerase 5B; poly [ADP-ribose] polymerase tankyrase-2; protein poly-ADP-ribosyltransferase tankyrase-2; TANK2; tankyrase II; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; tankyrase-like protein; tankyrase-related protein; TNKL; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2.
Gene ID
80351
Accession Number
NP_079511.1
Reactivity
Human
Immunogen
Range: Ser959 - Gly1166
Target
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunohistochemistry|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
127 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against TNKS2. It has been selected for its ability to recognize TNKS2 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
TNKS2
Host or Source
Rabbit
Protein Name
Tankyrase-2
Gene Name URL
TNKS2
Nucleotide Accession Number
NM_025235
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