NR5A2 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Nuclear receptor subfamily 5 group A member 2
Gene Aliases
Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; B1F; B1F2; CPF; CYP7A promoter-binding factor; fetoprotein-alpha 1 (AFP) transcription factor; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; Hepatocytic transcription factor; hepatocytic transcription factor hB1F-3; liver nuclear receptor homolog-1 variant 2; Liver receptor homolog 1; LRH1; LRH-1; nuclear receptor subfamily 5 group A member 2.
Gene ID
2494
Accession Number
NP_001263393
Reactivity
Human|Mouse
Immunogen
Recombinant Human Nuclear receptor subfamily 5 group A member 2 protein (182-291AA)
Target
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957) . Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
NR5A2
Host or Source
Rabbit
Protein Name
Nuclear receptor subfamily 5 group A member 2
Gene Name URL
NR5A2
Nucleotide Accession Number
NM_001276464
Curated Selection
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