CHTOP Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Chromatin target of PRMT1
Gene Aliases
C10orf77; C1orf77; chromatin target of PRMT1 protein; FL-SRAG; FOP; friend of PRMT1 protein; pp7704; Small arginine- and glycine-rich protein; small protein rich in arginine and glycine; SRAG; SRAG-3; SRAG-5.
Gene ID
26097
Accession Number
NP_001193541
Reactivity
Human|Mouse
Immunogen
Recombinant Human Chromatin target of PRMT1 protein (179-248AA)
Target
Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291) . May play a role in the silencing of fetal globin genes (PubMed:20688955) . Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity) . Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
CHTOP
Host or Source
Rabbit
Protein Name
Chromatin target of PRMT1 protein
Gene Name URL
CHTOP
Nucleotide Accession Number
NM_001206612
Curated Selection
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