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FBXL21 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

F-box and leucine rich repeat protein 21 (gene/pseudogene)

Gene Aliases

F-box and leucine-rich repeat protein 21; F-box and leucine-rich repeat protein 3B; F-box/LRR-repeat protein 3B.

Gene ID

26223

Accession Number

NP_036291

Reactivity

Human|Mouse

Immunogen

Recombinant Human F-box/LRR-repeat protein 21 protein (78-137AA)

Target

Substrate-recognition component of the SCF (FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF (FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF (FBXL21) complex counteracts the activity of the SCF (FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Western blot

Purification

Protein G Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Format

Liquid

Reconstitution

-20°C or -80°C

Fragment

IgG

NCBI Gene Symbol

FBXL21

Host or Source

Rabbit

Protein Name

F-box/LRR-repeat protein 21

Gene Name URL

FBXL21

Nucleotide Accession Number

NM_012159

Frequently Asked Questions

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