WAC Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
WW domain containing adaptor with coiled-coil
Gene Aliases
BM-016; DESSH; PRO1741; WW domain-containing adapter protein with coiled-coil; Wwp4.
Gene ID
51322
Accession Number
NP_057712
Reactivity
Human
Immunogen
Recombinant Human WW domain-containing adapter protein with coiled-coil protein (10-102AA)
Target
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877) . Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877) . Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877) . Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037) . Also acts as a negative regulator of basal autophagy (PubMed:26812014) . Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014) . May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
WAC
Host or Source
Rabbit
Protein Name
WW domain-containing adapter protein with coiled-coil
Gene Name URL
WAC
Nucleotide Accession Number
NM_016628
Frequently Asked Questions
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