RNF125 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Ring finger protein 125
Gene Aliases
E3 ubiquitin-protein ligase RNF125; RING finger protein 125; ring finger protein 125, E3 ubiquitin protein ligase; T-cell RING activation protein 1; T-cell ring protein identified in activation screen; TNORS; TRAC1; TRAC-1.
Gene ID
54941
Accession Number
NP_060301
Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase RNF125 protein (143-231AA)
Target
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375) . Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729) . Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766) . Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934) . Acts as a positive regulator of T-cell activation (PubMed:15843525) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
RNF125
Host or Source
Rabbit
Protein Name
E3 ubiquitin-protein ligase RNF125
Gene Name URL
RNF125
Nucleotide Accession Number
NM_017831
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