USP2 Antibody

41 kDa ubiquitin-specific protease; deubiquitinating enzyme 2; ubiquitin carboxyl-terminal hydrolase 2; ubiquitin specific protease 12; ubiquitin specific protease 9; ubiquitin thioesterase 2; ubiquitin-specific-processing protease 2; UBP41; USP9.

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19917254, PubMed:19838211) . Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity) . Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (PubMed:17290220, PubMed:19838211) . Has no deubiquitinase activity against p53/TP53 (PubMed:17290220) . Prevents MDM2-mediated degradation of MDM4 (PubMed:17290220) . Plays a role in the G1/S cell-cycle progression in normal and cancer cells (PubMed:19917254) . Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (By similarity) . Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (By similarity) . Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity) . Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity) .

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol