Lansoprazole sulfone

Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H+, K+-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H+, K+-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease[1][2].

Product Specifications

CAS Number

[131926-99-3]

Product Name Alternative

AG-1813

UNSPSC

12352005

Hazard Statement

H225, H315, H319

Target

Drug Metabolite; Proton Pump

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/lansoprazole-sulfone.html

Purity

99.52

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=S(C1=NC2=CC=CC=C2N1)(CC3=NC=CC(OCC(F)(F)F)=C3C)=O

Molecular Formula

C16H14F3N3O3S

Molecular Weight

385.36

Precautions

H225, H315, H319

References & Citations

[1]Swamy G, et al. Crystal structure of lansoprazole sulfone[J]. Journal of Structural Chemistry, 2007, 48: 715-718.|[2]Karol MD, et al. Lansoprazole pharmacokinetics in subjects with various degrees of kidney function. Clin Pharmacol Ther. 1997 Apr;61 (4) :450-8.