RGS14 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Regulator of G protein signaling 14
Gene Aliases
Regulator of G-protein signaling 14.
Gene ID
10636
Accession Number
NP_006471
Reactivity
Human
Immunogen
Recombinant Human Regulator of G-protein signaling 14 protein (230-510AA)
Target
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI) . Has GDI activity on G (i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G (o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF) -stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G (i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G (i) -alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF) -mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
RGS14
Host or Source
Rabbit
Protein Name
Regulator of G-protein signaling 14
Gene Name URL
RGS14
Nucleotide Accession Number
NM_006480
Frequently Asked Questions
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