ZBTB48 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Zinc finger and BTB domain containing 48

Gene Aliases

GLI-Kruppel family member HKR3; HKR3; krueppel-related zinc finger protein 3; pp9964; telomere zinc finger-associated protein; telomeric zinc finger-associated protein; TZAP; zinc finger and BTB domain-containing protein 48; zinc finger protein 855; ZNF855.

Gene ID

3104

Accession Number

NP_001265576

Reactivity

Human|Mouse

Immunogen

Recombinant Human Telomere zinc finger-associated protein (1-280AA)

Target

Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411) . Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411) . Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411) . Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257) . Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257) . Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177) . Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol