ABT-639
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker.
Product Specifications
CAS Number
[1235560-28-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ABT-639.html
Purity
99.32
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
O=S(C1=CC(C(N2C[C@](CCC3)([H])N3CC2)=O)=C(Cl)C=C1F)(NC4=CC=CC=C4F)=O
Molecular Formula
C20H20ClF2N3O3S
Molecular Weight
455.91
Precautions
H302, H315, H319, H335
References & Citations
[1]Jarvis MF, et al. A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats. Biochem Pharmacol. 2014 Jun 15;89 (4) :536-44.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
T-type calcium channel
Available Sizes
Curated Selection
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