PARP3 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Poly (ADP-ribose) polymerase family member 3

Gene Aliases

ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) -like 2; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) -like 3; ADP-ribosyltransferase diphtheria toxin-like 3; ADPRT3; ADPRT-3; ADPRTL2; ADPRTL3; ARTD3; DNA ADP-ribosyltransferase PARP3; IRT1; NAD (+) ADP-ribosyltransferase 3; NAD+ ADP-ribosyltransferase 3; PADPRT-3; poly [ADP-ribose] polymerase 3; poly (ADP-ribose) synthetase-3; poly[ADP-ribose] synthase 3; poly[ADP-ribose] synthetase 3; protein mono-ADP-ribosyltransferase PARP3.

Gene ID

10039

Accession Number

NP_001003931

Reactivity

Human|Mouse

Immunogen

Recombinant Human Poly [ADP-ribose] polymerase 3 protein (294-533AA)

Target

Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Western blot

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol