K-252c

K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase[1][2][3].

Product Specifications

CAS Number

[85753-43-1]

UNSPSC

12352005

Hazard Statement

H302-H319

Target

Apoptosis; Bacterial; Beta-lactamase; PKC

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Epigenetics; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/k-252c.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)NC6=C3C=CC=C6

Molecular Formula

C20H13N3O

Molecular Weight

311.34

Precautions

P264-P270-P280-P305+P351+P338-P330-P501

References & Citations

[1]Pereira, E.R., et al. Structure-activity relationships in a series of substituted indolocarbazoles: Topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties J. Med. Chem. 39 (22), 4471-4477 (1996) .|[2]Liu, R., et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2 Arch. Pharm. Res. 30 (3), 270-274 (2007) .|[3]Zimmermann, A., et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase Antiviral Res. 48 (1), 49-60 (2000) .|[4]McGovern, S.L., et al. Kinase inhibitors: Not just for kinases anymore Journal of Medicinal Chemistry 46, 1478-1483 (2003) .