TP53 Antibody - Biotin Conjugated
Product Specifications
CAS Number
9007-83-4
Gene Name
Tumor protein p53
Gene Aliases
Cellular tumor antigen p53; p53; transformation related protein 53; Trp53; tumor protein p53 (Li-Fraumeni syndrome) ; tumor suppressor p53.
Gene ID
24842
Accession Number
NP_000537.3NP_001119584.1NP_001119585.1NP_001119586.1NP_001119587.1NP_001119588.1
Reactivity
Rat
Immunogen
Recombinant Rat Cellular tumor antigen p53 protein (1-391AA)
Target
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Format
Liquid
Buffer
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
Tp53
Host or Source
Rabbit
Protein Name
Cellular tumor antigen p53
Gene Name URL
Tp53
Nucleotide Accession Number
NM_000546.5NM_001126112.2NM_001126113.2NM_001126114.2NM_001126115.1NM_001126116.1
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