GRIA2 Antibody - Biotin Conjugated

Product Specifications

CAS Number

9007-83-4

Gene Name

Glutamate ionotropic receptor NMDA type subunit 2A

Gene Aliases

EPND; FESD; GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; glutamate ionotropic receptor NMDA 2A; glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; LKS; NMDAR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NR2A.

Gene ID

2903

Accession Number

NP_000817.2NP_001077088.1NP_001077089.1

Reactivity

Human

Immunogen

Recombinant Human Glutamate receptor ionotropic, NMDA 2A protein (501-750AA)

Target

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg (2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280) . Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626) . Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity) .

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Enzyme-linked immunosorbent assay

Purification

Protein G Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol