DNMT3A Antibody - FITC Conjugated
Product Specifications
Gene Name
DNA methyltransferase 3 alpha
Gene Aliases
Cysteine methyltransferase DNMT3A; DNA (cytosine-5-) -methyltransferase 3 alpha; DNA (cytosine-5) -methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNMT3A2; HESJAS; M.HsaIIIA; TBRS.
Gene ID
1788
Accession Number
NP_072046.2NP_715640.2NP_783328.1NP_783329.1XP_005264232.1XP_005264234.1
Reactivity
Human
Immunogen
Recombinant Human DNA (cytosine-5) -methyltransferase 3A protein (680-902AA)
Target
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Clonality
Polyclonal
Conjugation
FITC
Type
Polyclonal Antibody
Applications
WB
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Format
Liquid
Buffer
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
DNMT3A
Host or Source
Rabbit
Protein Name
DNA (cytosine-5) -methyltransferase 3A
Gene Name URL
DNMT3A
CAS Number
9007-83-4
Nucleotide Accession Number
NM_022552.4NM_153759.3NM_175629.2NM_175630.1XM_005264175.3XM_005264177.3
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