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EPHA7 Antibody (OABF01776-100UL)

Product Specifications

CAS Number

9007-83-4

Gene Name

EPH receptor A7

Gene Aliases

EHK3; EHK-3; EK11; EPH homology kinase 3; Eph homology kinase-3; EPH-like kinase 11; ephrin type-A receptor 7; HEK11; receptor protein-tyrosine kinase HEK11; tyrosine-protein kinase receptor EHK-3.

Gene ID

2045

Reactivity

Bovine|Chicken|Dog|Horse|Human|Mouse|Rabbit|Rat

Immunogen

KLH conjugated synthetic peptide derived from human EphA7

Target

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase (CASP3) -dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot

Purification

Protein A Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1 ug/ul

Format

Liquid.// Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

Reconstitution

-20°C

Fragment

IgG

Specificity

There is a chance that this protein will cross-react with EphA4 based on a 73% non-sequential sequence similarity.

NCBI Gene Symbol

EPHA7

Host or Source

Rabbit

Protein Name

Ephrin type-A receptor 7

Gene Name URL

EPHA7

Frequently Asked Questions

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