EPHA7 Antibody (OABF01776-100UL)
Product Specifications
CAS Number
9007-83-4
Gene Name
EPH receptor A7
Gene Aliases
EHK3; EHK-3; EK11; EPH homology kinase 3; Eph homology kinase-3; EPH-like kinase 11; ephrin type-A receptor 7; HEK11; receptor protein-tyrosine kinase HEK11; tyrosine-protein kinase receptor EHK-3.
Gene ID
2045
Reactivity
Bovine|Chicken|Dog|Horse|Human|Mouse|Rabbit|Rat
Immunogen
KLH conjugated synthetic peptide derived from human EphA7
Target
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase (CASP3) -dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
Purification
Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 ug/ul
Format
Liquid.// Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Reconstitution
-20°C
Fragment
IgG
Specificity
There is a chance that this protein will cross-react with EphA4 based on a 73% non-sequential sequence similarity.
NCBI Gene Symbol
EPHA7
Host or Source
Rabbit
Protein Name
Ephrin type-A receptor 7
Gene Name URL
EPHA7
Frequently Asked Questions
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