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AGER Antibody (OABF00086-100UL)

Product Specifications

CAS Number

9007-83-4

Gene Name

Nuclear receptor subfamily 3 group C member 1

Gene Aliases

GCCR; GCR; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; GR; GRL; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3 group C member 1 variant hGR-B (54) ; nuclear receptor subfamily 3 group C member 1 variant hGR-B (77) ; nuclear receptor subfamily 3 group C member 1 variant hGR-B (93) ; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) .

Gene ID

2908

Swiss Prot

Q92769

Reactivity

Human

Immunogen

A synthesized peptide derived from human GR

Clonality

Recombinant Monoclonal

Conjugation

Unconjugated

Type

Polyclonal Antibody

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Dilution

Receptor for glucocorticoids (GC) (PubMed:27120390) . Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696) . Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514) . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity) .

Format

Liquid

Reconstitution

-20°C or -80°C

NCBI Gene Symbol

NR3C1

Protein Name

Glucocorticoid receptor

Gene Name URL

NR3C1

Frequently Asked Questions

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