Human PLCG1 Antibody : SureLight 488 (Phospho-Tyr783)
Product Specifications
CAS Number
9007-83-4
Gene Name
Phospholipase C gamma 1
Gene Aliases
PLC1, NCKAP3, PLC-II, PLC148, PLCgamma1
Gene ID
5335
Swiss Prot
P19174
Accession Number
NP_002651.2
Reactivity
Mouse, Rat
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr783 of human phospho PLCγ1
Target
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor) -activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Clonality
Monoclonal
Clone
PLCG1Y783-C4
Conjugation
SureLight 488
Type
Monoclonal Antibody
Applications
FC
Purification
Protein A+G
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Format
Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA.
Reconstitution
2-8C
Fragment
Rabbit IgG1k
NCBI Gene Symbol
PLCG1
Host or Source
Rabbit
Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Gene Name URL
PLCG1
Nucleotide Accession Number
NM_002660.2
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