Human PTPN11 Antibody : FITC (Phospho-Tyr580)
Product Specifications
Gene Name
Protein tyrosine phosphatase non-receptor type 11
Gene Aliases
CFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2, SH-PTP3
Gene ID
5781
Swiss Prot
Q06124
Accession Number
NP_001317366.1
Reactivity
Mouse, Rat
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr580 of human phospho Shp2
Target
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Clonality
Monoclonal
Clone
Shp2Y580-4A2
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Monoclonal Antibody
Applications
FC
Purification
Protein A+G
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Format
Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA.
Reconstitution
2-8C
Fragment
Rabbit IgG1k
NCBI Gene Symbol
PTPN11
Host or Source
Rabbit
Protein Name
Tyrosine-protein phosphatase non-receptor type 11
Gene Name URL
PTPN11
CAS Number
9007-83-4
Nucleotide Accession Number
NM_001330437.1
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