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Human PTPN11 Antibody (Phospho-Tyr580)

Product Specifications

CAS Number

9007-83-4

Gene Name

Protein tyrosine phosphatase non-receptor type 11

Gene Aliases

CFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2, SH-PTP3

Gene ID

5781

Swiss Prot

Q06124

Accession Number

NP_001317366.1

Reactivity

Mouse, Rat

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Tyr580 of human phospho Shp2

Target

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Clonality

Monoclonal

Clone

Shp2Y580-4A2

Conjugation

Unconjugated

Type

Monoclonal Antibody

Applications

FC

Purification

Protein A+G

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Format

Liquid. 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA.

Reconstitution

-20C

Fragment

Rabbit IgG1k

NCBI Gene Symbol

PTPN11

Host or Source

Rabbit

Protein Name

Tyrosine-protein phosphatase non-receptor type 11

Gene Name URL

PTPN11

Nucleotide Accession Number

NM_001330437.1

Frequently Asked Questions

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